The victims ranged in age from 12 to 16 years old.
The shots got the attention of a nearby shop owner and his 12-year-old son, who both came outside to investigate. When more shots were fired, the two retreated back into the store, where they discovered the 12-year-old had been struck by a bullet in the torso.
The boy was later pronounced dead at the scene.
The father was uninjured.
The five teens who were shot and taken to University Hospitals, where one remains confined with a gunshot wound to the head.
There have been no arrests, but police say the suspects were wearing black or darkly-colored hoodies and are also likely juveniles.
A vigil is being organized by several community groups to be held Saturday night.