Siegel, 70, announced his departure in a farewell message published on NPR’s website Friday.
“And so, for the last time I’m signing off, proud of my association with this unique institution, mindful of things I might have done better, grateful for the company of thousands of gifted colleagues, and thankful to you, for being — as we used to say in those hackneyed but truthful fundraising messages — for being the public in public radio,” he wrote.
A New York native, Siegel came to NPR after being laid off from his job at the New York FM radio station when it was sold in 1976.
He worked at NPR for 41 years, and hosted All Things Considered for the past 30 years.
The popular news program was the first of its kind on NPR, premiering on May 3, 1971.
Siegel’s work with NPR took him across the globe, with reports from Europe, the Middle East, North Africa, and Asia.